Race-Specific Differences in Endothelial Function

Race-specific differences in endothelial function: predisposition of African Americans to vascular diseases.

BACKGROUND The prevalence of the endothelium-impaired function disorders, such as hypertension and diabetes mellitus, and the severity of their complications are considerably greater in blacks than whites. Evidence has accumulated that superoxide (O2-) production and its interaction with nitric oxide (NO), yielding the strong oxidant peroxynitrite (ONOO-), play central roles in vascular pathoph...

Race Differences in Intelligence

Metoprolol improves endothelial function in patients with cardiac syndrome X

Endothelial dysfunction which is manifested by the loss of nitric oxide bioavailability, is an increasingly recognized cause of cardiac syndrome X (CSX) and beta blockers are used for the treatment of this syndrome. Thus, the aim of this study was to investigate effects of metoprolol, as a beta blocker, on endothelial function in CSX patients. The study included 25 CSX patients (20 female/ 5 ma...

Explaining Race Differences in IQ

The claim that there are genetic racial differences in IQ has been based mainly on two grounds: the evidence for high within-race heritability for IQ and the failure of various environmental explanations to account completely for mean racial differences. However, neither of these has direct relevance to the question of whether race differences in IQ have mainly a genetic or mainly an environmen...

Intrinsic sex-specific differences in microvascular endothelial cell phosphodiesterases.

The importance of gonadal hormones in the regulation of vascular function has been documented. An alternate and essential contribution of the sex chromosomes to sex differences in vascular function is poorly understood. We reported previously sex differences in microvessel permeability (P(s)) responses to adenosine that were mediated by the cAMP signaling pathway (Wang J, PhD thesis, 2005; Wang...